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J B Parys Selected Research

Inositol 1,4,5-Trisphosphate

5/2013IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2.
8/2002IP(3)-mediated Ca(2+) signals in human neuroblastoma SH-SY5Y cells with exogenous overexpression of type 3 IP(3) receptor.
11/2001Calcium puffs are generic InsP(3)-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses.

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J B Parys Research Topics

Disease

4Neuroblastoma
08/2002 - 02/2000
2B-Cell Lymphoma (Lymphoma, B Cell)
05/2013 - 02/2012
2Alzheimer Disease (Alzheimer's Disease)
07/2000 - 01/2000
2Malignant Hyperthermia
07/2000 - 01/2000
2Brody myopathy
07/2000 - 01/2000
2Spinocerebellar Ataxias (Spinocerebellar Ataxia)
07/2000 - 01/2000
2Hypokalemic Periodic Paralysis (Periodic Paralysis, Hypokalemic)
07/2000 - 01/2000
2Central Core Myopathy (Central Core Disease)
07/2000 - 01/2000
1Polycythemia (Erythrocytosis)
02/2016
1Leukopenia
02/2016
1Neoplasms (Cancer)
05/2013
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
05/2013
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
05/2013
1Benign Familial Pemphigus (Hailey Hailey Disease)
08/2003
1Prostatic Neoplasms (Prostate Cancer)
07/2003
1Hyperglycemia
05/2001
1Migraine Disorders (Migraine)
07/2000
1Cardiomegaly (Heart Hypertrophy)
07/2000
1Major Affective Disorder 2
07/2000
1Diabetes Mellitus
07/2000
1Lambert-Eaton Myasthenic Syndrome (Lambert-Eaton Syndrome)
07/2000
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
07/2000
1Episodic Ataxia
07/2000
1Epilepsy (Aura)
07/2000
1Migraine with Aura (Familial Hemiplegic Migraine)
01/2000
1Bipolar Disorder (Manic Depressive Psychosis)
01/2000
1Type 2 Episodic Ataxia
01/2000
1Nervous System Diseases (Neurological Disorders)
01/2000
1Oculocerebrorenal Syndrome (Lowe Syndrome)
01/2000

Drug/Important Bio-Agent (IBA)

3Inositol 1,4,5-TrisphosphateIBA
05/2013 - 11/2001
2Proteins (Proteins, Gene)FDA Link
02/2016 - 07/2000
2Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)IBA
05/2013 - 02/2012
2Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA
07/2000 - 01/2000
1Inosine Diphosphate (IDP)IBA
05/2013
1Peptides (Polypeptides)IBA
05/2013
1Adenosine Triphosphatases (ATPase)IBA
08/2003
1CalciumIBA
07/2003
1Adenosine Triphosphate (ATP)IBA
07/2003
1AndrogensIBA
07/2003
1Complementary DNA (cDNA)IBA
08/2002
1Retinal Pigments (Pigments, Visual)IBA
05/2001
1Protein Kinase CIBA
05/2001
1Connexin 43 (Connexin43)IBA
05/2001
1Inositol (Myoinositol)IBA
07/2000
1AntibodiesIBA
07/2000
1L-Type Calcium Channels (Dihydropyridine Receptor)IBA
07/2000
1Indicators and Reagents (Reagents)IBA
06/2000
1DigitoninIBA
06/2000
1Fluo-3IBA
06/2000
1Glutamic Acid (Glutamate)FDA Link
01/2000

Therapy/Procedure

1Lasers (Laser)
02/2000